In my understanding, mmap'ing a file that fits into RAM will be like having the file in memory.
Say that we have 16G of RAM, and we first mmap a 10G file that we use for a while. This should be fairly efficient in terms of access. If we then mmap a second 10G file, will that cause the first one be swapped out? Or parts of it? If so, when will this happen? At the mmap call, or on accessing the memory area of the newly loaded file?
And if we want to access the memory of the pointer for the first file again, will that make it load the swap the file in again? So, say we alternate reading between memory corresponding to the first file and the second file, will that lead to disastrous performance?
Lastly, if any of this is true, would it be better to mmap several smaller files?
As has been discussed, your file will be accessed in pages; on x86_64 (and IA32) architectures, a page is typically 4096 bytes. So, very little if any of the file will be loaded at mmap time. The first time you access some page in either file, then the kernel will generate a page fault and load some of your file. The kernel may prefetch pages, so more than one page may be loaded. Whether it does this depends on your access pattern.
In general, your performance should be good if your working set fits in memory. That is, if you're only regularly accesning 3G of file across the two files, so long as you have 3G of RAM available to your process, things should generally be fine.
On a 64-bit system there's no reason to split the files, and you'll be fine if the parts you need tend to fit in RAM.
Note that if you mmap an existing file, swap space will not be required to read that file. When an object is backed by a file on the filesystem, the kernel can read from that file rather than swap space. However, if you specify MMAP_PRIVATE in your call to mmap, swap space may be required to hold changed pages until you call msync.