I'm embarking on a project where accessibility to WCAG 2.0 and the ability to use the web application in the JAWS screenreader are key requirements.
I'm looking for insights as to how JAWS treats Javascript, is it a complete no go or is JAWS smart enough to cope!?
jaws doesn't know about javascript, it just reads screen and makes some actions. It's just a plugin for browser.
I was working on a project with similar requirements not so long ago. We've used YAML css framework which is designed for accessibility. And we've used only a few ajax and javascript improvements.
And I hope that this and this link will help you too.