Here is the statement from my textbook that made me confused as to what "instruction profile" meant:
"...new peripheral devices constantly change the nature of the demand on the system in terms of typical instruction profile and the data access patterns."" - Computer Organization and Architecture: Designing for Performance 10th edition
When searching around for a definition for instruction profile, I wasn't able to find one. I found results for instructional profiles which are used in teaching/pedagogy, a pdf showing a graph that used the term instructional profile but seemed to not be in computing, but not a definition for instruction profile.
In this context, it is likely that instruction profile means the types, variety, and organisation (the 'profile') of machine-code instructions being executed on the device.
It isn't a term I have heard before, and one I doubt will suddenly jump into mainstream use, but it is really just saying "new peripherals mean that the types of code running on computers is becoming ever more varied".