Say I set a break-point on a line of code in Firefox devtools/Debugger and refresh the webpage to stop at that line. Can I skip the execution of that line and jump directly to the next line?
No, it's currently not possible (as of Firefox 101) to skip lines when debugging.
What you may do is manipulate the code while you're debugging. E.g. you can reset the value of a variable when it gets a new value assigned while the execution is stopped at a breakpoint. Or when the next statement is a function call, you can replace that function by an empty one. Of course, it is not always possible to turn a statement into a no-op. And doing so may have side effects.