My button doesn't seem to be responsive. Although I have a EventSystem in my hierarchy.
This is my canvas inside the inspector, I have another Canvas in my scene called "Shop Canvas", but it has the same inspector values.
I had a similar issue of not being able to engage with a button. The reason being there was another UI component with ray cast enabled that did not allow inputs to reach the button.
For your case, I think it's the "The things...". Try disabling that and see if you can engage with the button again.