When I saw this article about using a python-like sintax (indentation based, without curly braces, syntax) for C#, I begun to wonder: can I have an IDE that parses and compiles it?
What about Iron Python? It's python for dotnet.
You can also check out Delphi Prism (runs as a plugin for Visual Studio) if you don't like braces. It can do everything that C# does, plus a few extra things.