When I opened up Visual Studio 2010 this morning, my Menu Bar (you know, the bar with File, Edit, etc. on it) was missing. I've tried all of the right-click menus, customize options, Function keys and Google searches that I can think of but to no avail.
Sounds like registry damage, HKCU\Software\Microsoft\VisualStudio\10.0_Config perhaps. Try running devenv.exe with the /ResetSettings command line option first. Next is rerunning setup.exe and choosing the Repair option.