I'm trying to adapt to the situation in which a user has no email client installed (like in my case: i use opera's internal mail client, so if i click a mailto: link i internet explorer i won't get anything.))
At the moment it is not possible. The closest thing to an answer I ended up with this:
<a id="mail-link" href="mailto:the@email.it" onclick="if (this.hasAttribute('data-clickedonce')) {this.setAttribute('href','mailform.php?to=the@email.it');} this.setAttribute('data-clickedonce','yes');">Send a Mail</a>
The script embedded in the a tag changes the href on the second press. The theory is: if the user has no way to handle the mail protocol, nothing happens and he/she will certainly try to click the link another time.