Setup: Emacs 24.2.1 running on Ubuntu 13.04 Using version provided by the software center ("modified by Debian").
Issue: The binding "C-c C-c" is not recognized with python.el (it does work on python-mode.el) even though C-h b lists it as a valid combination associated with "python-send-buffer".
The troubleshooting section in http://www.emacswiki.org/emacs/ProgrammingWithPythonDotEl suggests it has to do with the point needing to be at the "very bottom" but the solution provided seems to be for C-c C-r and I don't know if it applies to C-c as well.
Also similar to: https://lists.gnu.org/archive/html/emacs-devel/2007-09/msg01665.html
As the python.el shipped now is different from 24.2, seems to cure on Ubuntu's side only:
https://bugs.launchpad.net/ubuntu
Also consider installing latest release.