Recently I updated Wine (among other things) via port selfupdate from version 1.2 to version 1.4. After that it takes roughly a minute to start up, even simple things such as wine cmd or winecfg. CPU usage also spikes to about 140%.
I've tried completely removing and re-installing MacPorts (yes, I removed ~/.wine) and it's still as slow.
How do I get to the bottom of this?
On 2012-03-20 I updated fontconfig to 2.9.0_0; fontconfig is used by wine and other ports to find fonts. Unfortunately there was a problem where fontconfig did not create its cache files correctly, causing it to try to recreate them each time you use a program that uses fontconfig; this could take a minute or more, depending on your disk speed and how many fonts you have installed, since it's indexing all your fonts.
I updated fontconfig to 2.9.0_1 on 2012-03-27 with a patch to fix this so the usual "sudo port selfupdate" and "sudo port upgrade outdated" commands should fix this.