Found that the question was pondered a few years ago: https://github.com/dotnet/fsharp/issues/8688
My code looks like
#r "nuget: Microsoft.NETCore.App"
#r "nuget: Microsoft.NETCore.App.Ref"
#r "nuget: Microsoft.AspNetCore"
open Microsoft.AspNetCore.Builder
let builder = WebApplication.CreateBuilder(args)
But that does not work.
This hosts a minimal API in a script:
#r @"C:\Program Files\dotnet\shared\Microsoft.AspNetCore.App\9.0.0\Microsoft.AspNetCore.Http.Abstractions.dll"
#r @"C:\Program Files\dotnet\shared\Microsoft.AspNetCore.App\9.0.0\Microsoft.AspNetCore.dll"
#r @"C:\Program Files\dotnet\shared\Microsoft.AspNetCore.App\9.0.0\Microsoft.AspNetCore.Routing.dll"
open System
open Microsoft.AspNetCore.Builder
let builder = WebApplication.CreateBuilder()
let app = builder.Build()
app.MapGet("/time", Func<_>(fun _ -> DateTime.Now))
app.MapGet("/lab", Func<_,_>(fun ([<FromQuery>] n: int) -> {| a=2; n=n |}))
app.Run()