I create a instance VM in google cloud computer engine with a Wordpress with bitnami implementation, when i´m editing the site, ip is reached and dont work moretime.
The below points can be taken into consideration for resolving your issue.
Incoming firewall rules for your instance should be using port 80 for HTTP and port 443 for HTTPS. Ensure these ports are not used by another application or blocked by a firewall.
Console->VPCnetwork->Firewall
Check your web server status and restart if needed.
To restart a Web server,try below commands based on your application.
For Apache: Sudo service apache restart
For Nginx: Sudo nginx apache restart
For Database: Sudo mysql apache restart
SSH session-> sudo nano /opt/bitnami/apps/wordpress/htdocs/wp-config.php
Another possibility is to increase the memory limit of PHP in wp-config. php. If you are using shared hosting, you may have to ask your hosting provider to increase your memory limit. This allows you to run heavy plugins successfully which helps wordpress site to run longer.
Try bypassing DNS issues or recheck your DNS configuration and restart your VM instance. Directly access the IP address http://your-instance-ip and if it works then the problem is with your DNS.
Plugins: Some plugins can cause the application to show a warning or directly crash. This is due to incompatibilities with the WordPress version or some special Apache requirements (such as using .htaccess files). Disabling or removing the conflicting plugin solves the issue.
For more information you can refer to the official documentation.
UPDATE:
To fix a problem related to ERR_CONNECTION_REFUSED you can try the below commands by referring to the blog written by David Aladegbaiye Patricks.
sudo /opt/bitnami/ctlscript.sh startsudo service -status-allsudo /opt/bitnami/ctlscript.sh restart apache