I open a folder in Textmate, and select a file for editing. When I go to save the edited file, it indicates there is no parent folder, and asks if I want to create it. If I copy the edits, close without saving, re-open the file, paste the edits, and save, it saves correctly.
It seems like this is time dependent. The folder is on the local machine.
You should try Reverting to Defaults.
Because link only answers are frowned upon, here's the contents of that document as though said by Yoda:
By reverting to default settings, many problems may be solved.
Remove these folders, after quitting TextMate, you must.
Lose customizations, you will.
- ~/Library/Application Support/TextMate
- ~/Library/Caches/com.macromates.TextMate/BundlesIndex.binary
- ~/Library/Preferences/com.macromates.TextMate.plist
- ~/.tm_properties