I have Searched many hours on the internet but not found satisfactory so - What is the difference between VSTO Addin & COM Addin (which we make as Class library project and use excel object)? Is there any limitation in VSTO project like it will work for only specific Version of excel.
A COM Add-in uses the IDTExtensibility2 interface to communicate with an Office application.
VSTO (and any other Office Add-in library such as Add-in Express) bases on and extends this interface. For example, VSTO
VSTO works with Office 2007 and later (IDTExtensibility2 was introduced for Office 2000, if I remember correctly). You have to use the correct .NET Framework and VSTO template for the earliest version of Office you plan to support. Add-ins created for earlier versions can be used in later versions of Office without being re-built.
Any add-in based on the Interface is limited to Windows Desktop.