I got a new PC at work with Windows 10 Pro and had to setup iisnode on it...
I realized that I had missed a prerequisite:'IIS 7.x with IIS Management Tools and ASP.NET'
To enable this features, tried the UI option: Control Panel > Turn Windows features on or off > Internet Information Services > World Wide Web Services > Application Development Features
Reading different posts, I tried enabling apparently everything other than 'CGI'. upon selecting each feature, I got the error in the snapshot below... Tried the resolution here but to no avail... DISM Logs had:
After a while, I tried enabling the feature 'ASP.NET 4.7' only (some features were automatically selected by it)... this time it was smooth sailing through the UI.
http://localhost/node/ and its links worked like a charm
I documented the whole case here, hoping that it would help someone - Good luck !!