I have been asked if it is possible to have a sub-site of a MOSS site running a different hostname from the parent.
Say I had the following site hierachy:
Would it be possible to have the site running of www.my-moss-site.com but 'Sub Site' running off www.my-moss-sites-sub-site.com?
I know you can have multiple sites created through central admin which have different hostnames but I'm wondering if the above could also be achieved
No, this is only possible at the level of the Web Application. However, it might be possible if you put an ISA server (proxy server) in front of it. Now, I am no expert in the ISA server product from Microsoft - but a proxy server is the only possible solution as far as I can see. It can for instance also be employed to SSL enable SharePoint Web applications wihtout having to configure this in SharePoint.