I am looking to transfer a domain name to AWS route53. But I need to confirm how can I then set up a mail domain and use that mail domain to send mails from my .Net application with? Any big picture directions as well as details are both welcomed.
You can use AWS SES to send emails to AWS. After transferring the domain name to AWS Route53, you can whitelist the domain in AWS SES.
You can use AWS .NET SDK to send emails or use AWS SES SMTP credentials with a .NET SMTP library.