I downloaded 122 gb file of the complete blockchain to my computer with the download of the bitcoin core wallet. I would like to query against it locally using preferably node.js.
Any idea how I can do this?
You can use json RPC provided by bitcoin core.
You can call http calls via node.js.
see below.
https://en.bitcoin.it/wiki/API_reference_(JSON-RPC)#Node.js
or there are other third party libraries.
which are wrappers of above RPC calls.