I am creating an angular 2 application.
Using "uglify", able to do minify the TS/JS file, but while rendering, Is that possible to combine all JS file into 1 file,
In Angular CLI builds, all TS/JS files are merged into one and minified for production builds out of the box. Read how to use it on https://cli.angular.io/. Angular CLI is still in Beta though, so you should be ready for changes, which might require a migrating process.