This is the second time I've seen the error "Scripted Sandbox64.exe has stopped working" in Visual Studio 2015.
In my particular case, I was building a Windows Forms application and you place the application into the system tray in Windows. This application also writes files using System.IO. The project has nothing more than that. Visual Studio 2015 Community Edition crashes.
Disable the Diagnostic tool under
Tools -> Options -> Debugging -> General -> Enable Diagnostic Tools while debugging
More information: https://stackoverflow.com/a/31904957/2856307