When you debug a Visual Studio 2015 solution you see this error message:
Error while trying to run application: Invalid pointer
Obviously something isn't configured properly, or is permissions related, just wondering if anyone has identified the cause?
Using Jeremy's advice I reviewed the Activity Log (See here for info about the Activity Log) https://msdn.microsoft.com/en-us/library/bb166359.aspx
and found this error in the stack trace
....Access to the path 'C:\ProgramData\Microsoft Visual Studio\14.0\TraceDebugging\' is denied.]:...
The directory did not exist so I created it and was thereafter able to debug the project without the error.