I program regularly in R in a professional context, and I write packages for clients or co-workers as well. Some of the programmers here have a Java background and insist on doing everything the object-oriented way, using S4 methods. My experience on the other hand is that S4 implementations often perform worse and cause a lot more headache when trying to get the code do what you want it to do.
I definitely agree that in some cases, you have to be able to construct complex objects or append existing objects in a controlled manner. But most of the time, S4 implementations can easily be done using classic lists as well, without all the hassle like defining standardGeneric, methods, constructors, initializers and the likes.
When do you consider writing S4 implementations for R?
EDIT : For clarity, I do appreciate the answers and the discussion about OO in general in R. OOP can be done in numerous ways in R, but my question is really aimed at the added value of using S4 methods specifically.
I'm assuming this doesn't directly apply to you, but if you're developing packages for Bioconductor there's an incentive to use S4 as they actively encourage it's use and have for the better part of a decade now - so all of the core packages make heavy use of S4.
I find all of the extra overhead to be a pain - the setGeneric, setMethod, dealing with NAMESPACE, etc. That being said, I find that the structure that it imposes, potential for extensibility and other such things can be worth it. As with everything, there are tradeoffs involved. I think it can be a lot cleaner - I dislike how S3 methods are simply disguised by naming convention (foo.class). All that being said, I tend to avoid using S4 heavily in my own code unless I'm being told to do so.