I want to move the physical path of TFS Web Access Website (TFS 2015 on Server 2012 R2 and IIS 8) from the default path
C:\Program Files\Microsoft Team Foundation Server 14.0\Application Tier\Web Services
to another partition and path. I couldn't find anything similar on MSDN.
Is this scenario supported? Has anyone ever done that?
In Short: The scenario is not supported.
To move the whole TFS application and websites, you'll need to re-install the application tier and select another root folder during installation. But it is possible that the presence of common libraries from the previous installation will force you to the system partition.
You should be able to change the Cache folder for TFS through the admin console though: