Do i need to restart Apache after changing the settings.php file of a Drupal website?

I wanted to know the answer before I make the changes on a production server:

Do I need to restart Apache after changing the settings.php file of a Drupal website?

Solution

Simple answer is NO, as it is .php it is not cached by Apache it is not php.ini or something like that, Apache is caching only its own configs and settings.php is Drupal settings

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