In how many ways can an HTTP request be generated?
There are endless ways how you can create and from where you can send HTTP requests to a server. Actually your server has no idea, what the origin of such a request is (if it's AJAX or "regular" request, or sent from a console application or ...)
But there are HTTP methods (HTTP verbs) that (can) tell the server about the intent of the request: http://en.wikipedia.org/wiki/HTTP_Verbs#Request_methods
Also you can set headers in a request, for example the content-type or the accepted encoding: http://en.wikipedia.org/wiki/List_of_HTTP_header_fields Most JavaScript libraries for example set the (non-standard) HTTP header X-Requested-With, so your application can differentiate between regular and ajax requests.
You see, it's even possible to set your own, non-standard headers. There are endless possible combinations...