I recently tried to open the solution file (.sln) of my iOS-App and noticed it no longer works with Xamarin Studio.
The error message: Cannot cast from source type to destination type.
I've been using MSVC 2010 for app developement recently, so I guess this is another example of incompatibilities between Xamarin Studio and MSVC (I'm already used to messed-up "ItemGroups" in the .csproj files, but this seems to be something different).
The version of Xamarin Studio is 5.9.8 (build 0).
Maybe I should also file a bug at Xamarin.
Deleting the .userprefs file solved the problem.
Details: The root element contained a strange value for "DisabledProjects":
<Properties DisabledProjects="
 ">
Xamarin Studio failed to load that expression. Don't know where that came from though.