Ctrl-Shift-B, by default, builds an entire solution. An entire solution may contain many projects. Compiling all at the same time may be very slow, especially when development is only occurring on a single project.
I have tried t remap Ctrl-Shift-B to Build.BuildOnlyProject, but it does not work. Nothing happens.
From the menu, the following option does exactly what I want:
Build -> Build [MY PROJECT NAME]
The command is Build.BuildSelection
To bind that to a key, click Tools | Customize | Keyboard... then search for it to bind it.
Note: Build.BuildOnlyProject does not work all the way through VS2010, at least.