When I list keyspaces on my DSE cluster I get
myuser@cqlsh> DESC KEYSPACES;
dse_security system "OpsCenter" system_traces cfs
system_auth cfs_archive "HiveMetaStore" XXXXXXXX dse_system
where XXXXXXXX
is our internal keyspace and the rest are essentially systems keyspaces. Which of the above can easily be recreated without a backup? AFAIK, neither What are best practices for backing up a cassandra cluster? nor Backing up and restoring data in Datastax documentation answers this.
Installing Opscenter will create the "OpsCenter" keyspace. Installing DSE will re-create the other system keyspaces. I think the only ks you need to worry about is your own user-defined keyspace. Don't forget to backup your schema, you will need that in order to do the restore.