I am currently looking at developing a mobile apps for the S60 platform and is specifically looking at PyS60. It seems to suggest that the it can be compiled into native .sis files without the need for an embedded python interpreter. Reading through the documentations I could not find any statements where this is explicitly mentioned. While I am right now downloading the SDKs, Emulators, and the whole bunch of tool chains needed to test the development out on Linux, I thought I would ask here a bit while I am doing that.
Linux is not officially supported for Series60 development yet. You will save yourself a lot of headache using Windows, weirdly enough.
As far as Python is oncerned, I think the developed application is packaged into a .sis file but still requires the PyS60 interpreter to run once installed.