Say there is a database with 100+ tables and a major feature is added, which requires 20 of existing tables to be modified and 30 more added. The changes were done over a long time (6 months) by multiple developers on the development database. Let's assume the changes do not make any existing production data invalid (e.g. there are default values/nulls allowed on added columns, there are no new relations or constraints that could not be fulfilled).
What is the easiest way to publish these changes in schema to the production database? Preferably, without shutting the database down for an extended amount of time.
There is no generic answer on how to make 'changes' without downtime. The answer really depends from case to case, based on exactly what are the changes. Some changes have no impact on down time (eg. adding new tables), some changes have minimal impact (eg. adding columns to existing tables with no data size change, like a new nullable column that doe snot increase the null bitmap size) and other changes will wreck havoc on down time (any operation that will change data size will force and index rebuild and lock the table for the duration). Some changes are impossible to apply without *significant * downtime. I know of cases when the changes were applies in parallel: a copy of the database is created, replication is set up to keep it current, then the copy is changed and kept in sync, finally operations are moved to the modified copy that becomes the master database. There is a presentation at PASS 2009 given by Michelle Ufford that mentions how godaddy gone through such a change that lasted weeks.
But, at a lesser scale, you must apply the changes through a well tested script, and measure the impact on the test evaluation.
But the real question is: is this going to be the last changes you ever make to the schema? Finally, you have discovered the perfect schema for the application and the production database will never change? Congratulation, once you pull this off, you can go to rest. But realistically, you will face the very same problem in 6 months. the real problem is your development process, with developers and making changes from SSMS or from VS Server Explored straight into the database. Your development process must make a conscious effort to adopt a schema change strategy based on versioning and T-SQL scripts, like the one described in Version Control and your Database.