When building a SCORM solution from html and javascript where tracking with the LMS is required, is it still necessary to contain all pages in an IFRAME or are other approaches being adopted? What difficulties does working within an IFRAME present when trying to create responsive pages?
There's no need to use IFRAMES or OBJECTS to contain your SCORM content. The API is simply Javascript, and as long as it's all included in the page everything will work (the SCORM conformance reqs basically require you to look in your own frame, then any parent frames, then any parent window)...
Saying that - whatever platform you are using needs to allow you to have the content in there directly, and most simply put it into some sort of frame / window by default.