Do you know Audits tab from chrome's inspector? I just found out this tab's use and I think it is great but I wonder if the sugestions done there are reliable.
FOr example it says I shouln't use -webkit-border-radius, which seems right as it as a really old rule. Problem is... are this suggestions focused on a general good use of web developing for most common used browsers or are they refering to chrome only and more specifically to the current version of chrome?
If they're suggesting not too use a vendor specific prefix then that's because that rule has been pretty much accepted by everyone. The Google Chrome team have a lot to do with standards, as does Mozilla, Apple, Microsoft and Opera (along with many others).
A lot of the things are very generic performance guidelines to reduce page load time and you should be fine following them.