When I'm working with 2 objects there's no problem because all i have to do is toggle list[0] which would be first object that i selected (this is how i have it working below).
import maya.cmds as mc
sel_objs = mc.ls(sl = True)
mc.select(sel_objs[0], tgl = True)
thanks
You can replace the selection entirely with the last element of the list:
mc.select(sel_objs[-1], replace=True)
replace
is the equivalent to clicking on it rather than ctrl-clicking or shift-clicking. The selection is cleared in the action of selecting the new object.
sel_objs[-1]
returns the last object in the list, just as sel_objs[0]
returns the first object.