Is it possible to submit an iOS app to the App Store that only supports the 5 and 6 versions of the iPhone and doesn't support the iPhone 4s. The 4s has a different aspect ratio than the 5 and 6 and since I need the entire screen space my app won't look good on the 4s so for now I don't want to support it. Is this possible? If so, are there specific settings that I need to change in Xcode to do this?
Unfortunately, you have to support the iPhone 4S screen size.
Here's article 2.10 from the App Store Review Guidelines ( https://developer.apple.com/app-store/review/guidelines/#functionality ):
2.10 iPhone Apps must also run on iPad without modification, at iPhone resolution, and at 2X iPhone 3GS resolution
I guess if you have to support 2X iPhone 3GS resolution for iPad, you have to do it for iPhone as well.