I know A* is the most optimal algorithm for finding the shortest path, but I cannot see how any heuristic can work on a non lattice graph? This made me wonder whether or not A* is in fact capable of being used on an undirected or directed graph. If A* is capable of doing this, what kind of heuristic could one use? If A* is not, what is the current fastest algorithm for calculating the shortest path on a directed or undirected non lattice graph? Please comment if any more information is required.
It might be possible yes, but A* is a popular algorithm for finding shortest paths in grid like graphs. For graphs in general there are a lot of other algorithms for shortest path calculation which will match your case better. It depends on your setting which one to use.
If you plan to do a Single Source Shortest Path (SSSP), where you try to find the shortest path from one node to another one and your graph is unweighted you could use Breath-First-Search. A bidirectional version of this algorithm performs well in practice. If you do SSSP and your graph is weighted Dijkstra's algorithm is a common choice, a bidirectional version could be used as well. For all pairs shortest path other algorithms like Floyd-Warshall or Johnson's algorithm are useful.
If you want to use heuristics and estimate the distance before the search is done you can do pre calculations which are mostly applicable to each of the algorithms mentioned above. Some examples:
I would highly recommend that you identify your exact case and do some research for graph algorithms well suited to this one. A lot of research is done in shortest path for dozens of fields of application.