In the documentation it says "mostly used for debugging" which would lead me think "never enable it unless you've a problem and need to do some debugging," however reading mostly everything that I could find about it says to enable it "opcache.enable_cli 1" but why? I could not find any information concerning this matter, so if anybody knows, why should I enable it if the documentation basically says to keep it on 0?
Leave it off. It's primarily there for use while debugging issues with OPcache itself.
The opcache.enable_cli option enables PHP OPcache when running PHP scripts from the command line (using the php command). However, keep in mind that for PHP 5.x the OPcache extension works by storing cached opcodes in the memory of the current process. This is only useful when the process that's running PHP is going to be handling multiple requests that can reuse these opcodes, like in a web server or under FastCGI. For a process like the PHP CLI, which runs one "request" and exits, it just wastes memory and time.