This is more of a curiosity I suppose, but I was wondering whether it is possible to apply compiler optimizations post-compilation. Are most optimization techniques highly-dependent on the IR, or can assembly be translated back and forth fairly easily?
This has been done, though I don't know of many standard tools that do it.
This paper describes an optimizer for Compaq Alpha processors that works after linking has already been done and some of the challenges they faced in writing it.
If you strain the definition a bit, you can use profile-guided optimization to instrument a binary and then rewrite it based on its observable behaviors with regards to cache misses, page faults, etc.
There's also been some work in dynamic translation, in which you run an existing binary in an interpreter and use standard dynamic compilation techniques to try to speed this up. Here's one paper that details this.
Hope this helps!