"Node.js is limited to a single thread". how the nodeJS will react when we are deploying in Multi-Core systems? will it boost the performance?
The JavaScript running in the Node.js V8 engine is single-threaded, but the underlying libuv multi-platform support library is multi-threaded and those threads will be distributed across the CPU cores by the operating system according to it's scheduling algorithm, so with your JavaScript application running asynchronously (and single-threaded) at the top level, you still benefit from multi-core under the covers.
As others have mentioned, the Node.js Cluster module is an excellent way to exploit multi-core for concurrency at the application (JavaScript V8) level, and since Express is cluster aware, you can have multiple worker processes executing concurrent server logic, without needing a unique listening port for each process. Impressive.
As others have mentioned, you will need Redis or equivalent to share data among the cluster worker processes. You will also want a logging facility that is cluster aware, so the cluster master and all worker processes can log to a single shared log file. The Node log4node module is a good choice here, and it works with logrotate.
Typical web examples show using the runtime detected number of cores as the number of cluster worker processes to fork, but I prefer to make that a configuration option in a config.yaml file so I can tune the number of worker processes running the main JavaScript application as needed.