I have developed the Custom Wiki page layout and deployed it successfully but once I changed the layout its freeze pagelayout, save, checkout options?
I have checked with admin/siteowner user
Run on IE, Chrome, etc browsers also.
This is usually caused by one of or a few different issues, all of which are nearly impossible to troubleshoot remotely.
A couple of techniques that can be used to diagnose this further.
Start with the default template in sharepoint designer and keep changing slowly until you reach your final layout.
Wait for the page to timeout or view the console in developer tools to see if there is any details.