I'm using ExpressionEngine for a fairly high traffic site.
I have almost exactly the same setup at my office as I do at home. I use chrome most often on both machines.
Although I have no issues at the office, at home I am unable to login to my site successfully. Specifically the session cookie isn't set. This only occurs in IE and Chrome (as far as I've tested) and the cookie is set properly in Firefox. I used to be able to login through Chrome at home but haven't been able since I upgraded to Windows 8.
I've tried changing the cookie settings and even setting a rule specifically for the site but have had no success.
One of our staff members had a similar issue with her machine and I was never able to solve it but I would really like to figure out what's going.
Setting my system clock to the correct timezoned fixed the issue. My clock was set to the incorrect timezone and had been manually advanced a few hours. I believe this expired the cookies as soon as they were created.