What would you use for a brand new cross platform GUI app, CPython or IronPython ?
What about
- license / freedom
- development
- - doc
- - editors
- - tools
- libraries
- performances
- portability
What can you do best with one or the other ?
- networking
- database
- GUI
- system
- multi threading / processing
Use CPython, with IronPython you are bound to .Net platform which do not have much cross platform support, mono is there on linux but still for a cross platform app, I wouldn't recommend .Net.
So my suggestion is use CPython, for GUI use a framework like wxPython/PyQT and you would be happy.